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Shiv Nadar University

(SoNS) School of Natural Sciences

We show the bounds on five- and six-dimensional Universal Extra Dimension models from the result of the Higgs boson searches at the Large Hadron Collider and electroweak precision measurement. The latest data released by the ATLAS and the CMS gives the lower bounds on Kaluza-Klein scale which are from 650 GeV to 1350 GeV depending on models from Higgs to diboson/diphoton decay signal. The Higgs production cross section can be enhanced by factor 1.5 in crude estimation, diphoton decay signal is suppressed about 10%. Electroweak precision measurement also gives the lower bounds as from 700 GeV to 1500 GeV. This is a proceedings of the conference "Rencontres de Moriond EW 2013". © EW 2013.

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Physics

Proceedings of the 48th Rencontres de Moriond - 2013 Electroweak Interactions and Unified Theories, EW 2013

Constraint on universal extra dimensions from scalar boson searches

The norm of the mth derivative of the map that takes an operator to its fcth antisymmetric tensor power is evaluated. The case m = 1 has been studied earlier by Bhatia and Friedland [R. Bhatia and S. Friedland. Variation of Grassman powers and spectra. Linear Algebra and its Applications, 40:1-18, 1981]. For this purpose a multilinear version of a theorem of Russo and Dye is proved: it is shown that a positive m-linear map between C*-algebras attains its norm at the m-tuple (I,I,...,I). Expressions for derivatives of the maps that take an operator to its fcth tensor power and fcth symmetric tensor power are also obtained. The norms of these derivatives are computed. Derivatives of the map taking a matrix to its permanent are also evaluated.

Mathematics

Electronic Journal of Linear Algebra

Derivatives of tensor powers and their norms

In the area of catalysis, nanoparticles and enzymes are two of the most important systems. By amalgamating the two, we present here proof of the concept that it is possible to prepare a multifunctional catalyst that can carry out a "relay" reaction. The catalyst consists of a surface bound enzyme on a metalcore-silicashell nanoparticle architecture. Here the enzyme catalyzes the 1st reaction and the metal nanoparticles act as a catalyst for the 2nd reaction of the product from the 1st reaction. In particular, we have studied the catalytic activity of glucosidase grafted Au@mSiO2 on 4-nitrophenyl-β-glucopyranoside, where glucosidase will catalyse the 1st step to generate 4-nitrophenol, which acts as a substrate for the next reduction step which is catalysed by the Au nanoparticles present inside the mesoporous silica shell. © 2013 The Royal Society of Chemistry.

Chemistry

Fulltext

RSC Advances

Development of a multifunctional catalyst for a "relay" reaction

We examine some nontrivial consequences that emerge from interpreting a position-dependent mass (PDM)-driven Duffing oscillator in the presence of a quartic potential. The propagation dynamics is numerically studied and the sensitivity to the PDM-index is noted. Remarkable transitions from a limit cycle to chaos through period doubling and from a chaotic to a regular motion through intermediate periodic and chaotic routes are demonstrated. © 2013 IOP Publishing Ltd.

Journal of Physics A: Mathematical and Theoretical

Nonlinear dynamics of a position-dependent mass-driven Duffing-type oscillator

In response to the comment of Mustafa (2013 J. Phys. A: Math. Theor. 46 368001) we justify our stand of considering an extended Lagrange equation involving a non-conservative force term when the particle mass varies with position. As has been known for some time, such an extended form not only takes into account the principle of virtual work applied to D'Alembert's principle but yields precisely the form of Newton's equation expected for a particle possessing a position-dependent mass. © 2013 IOP Publishing Ltd.

Reply to Comment on 'Nonlinear dynamics of a position-dependent mass-driven Duffing-type oscillator'

Copper(II) complexes [Cu(Fc-aa)(cur)] (1-3) of curcumin (Hcur) and N-ferrocenylmethyl-l-amino acids (Fc-aa), viz., ferrocenylmethyl-l-tyrosine (Fc-TyrH), ferrocenylmethyl-l-tryptophan (Fc-TrpH) and ferrocenylmethyl-l- methionine (Fc-MetH), were prepared and characterized. The DNA photocleavage activity, photocytotoxicity and cellular localization in HeLa and MCF-7 cancer cells of these complexes were studied. Acetylacetonate (acac) complexes [Cu(Fc-aa)(acac)] (4-6) were prepared and used as controls. The chemical nuclease inactive complexes showed efficient pUC19 DNA cleavage activity in visible light. Complexes 1-3 showed high photocytotoxicity with low dark toxicity thus giving remarkable photodynamic effect. FACScan analysis showed apoptosis of the cancer cells. Fluorescence microscopic studies revealed primarily cytosolic localization of the complexes. {\textcopyright} 2013 Elsevier Masson SAS. All rights reserved.

European Journal of Medicinal Chemistry

Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids

The intramolecular Dötz benzannulation with alkyne-tethered aryloxy Fischer carbenes has been applied to synthesize a nine membered diaryl ether linked macrocyclic library. Insilico tools, that is, shape space analysis was used to assess the diversity of the library, and polar surface area (PSA) of the compounds were deduced to understand the range of their surface electrostatic potential. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Asian Journal of Organic Chemistry

Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation

Macroscopic properties of biomolecular systems are a straightforward consequence of time dependent microscopic interactions. Molecular Dynamics (MD) Simulations provide a time dependent microscopic properties of biomolecules, which could not be explained by experimental methods like X-ray crystallography. These specifications enable MD simulations as most widely used computational techniques for the study of dynamical properties of proteins, DNAs and other bio-macromolecules. In the present chapter, we focus the scopes, applicability and major case studies of MD simulations. The chapter also provides some lucid discussions about the pros and cons of free energy pathways like MM-PB (GB)/SA, LIE and other alchemical methods which are frequently used to study the binding mode of several biomolecular complexes. © 2013 by Apple Academic Press, Inc.

Nanoscience and Computational Chemistry: Research Progress

Molecular dynamics simulations: Applicability and scopes in computational biochemistry

HU is a non-sequence-specific DNA-binding protein and one of the most abundant nucleoidassociated proteins in the bacterial cell. Like Escherichia coli, the genome of Porphyromonas gingivalis is predicted to encode both the HUα (PG1258) and the HUβ (PG0121) subunit. We have previously reported that PG0121 encodes a non-specific DNA-binding protein and that PG0121 is co-transcribed with the K-antigen capsule synthesis operon. We also reported that deletion of PG0121 resulted in downregulation of capsule operon expression and produced a P. gingivalis strain that is phenotypically deficient in surface polysaccharide production. Here, we show through complementation experiments in an E. coli MG1655 hupAB double mutant strain that PG0121 encodes a functio nal HU homologue. Microarray and quantitative RT-PCR analysis were used to further investigate global transcriptional regulation by HUβ using comparative expression profiling of the PG0121 (HUβ) mutant strain to the parent strain, W83. Our analysis determined that expression of genes encoding proteins involved in a variety of biological functions, including iron acquisition, cell division and translation, as well as a number of predicted nucleoid associated proteins were altered in the PG0121 mutant. Phenotypic and quantitative real-time-PCR (qRT-PCR) analyses determined that under iron-limiting growth conditions, cell division and viability were defective in the PG0121 mutant. Collectively, our studies show that PG0121 does indeed encode a functional HU homologue, and HUβ has global regulatory functions in P. gingivalis; it affects not only production of capsular polysaccharides but also expression of genes involved in basic functions, such as cell wall synthesis, cell division and iron uptake. © 2013 SGM.

Life Sciences

Microbiology (United Kingdom)

The nucleoid-associated protein HUβ affects global gene expression in porphyromonas gingivalis

Cysticercosis is caused by larval stage of tape worms Taenia solium (T. solium). Human beings get infected by eating undercooked pork or vegetables and drinking contaminated water infected with eggs of T. solium. Human cysticercosis commonly manifests as subcutaneous and intramuscular nodules. This study highlights the role of fine needle aspiration cytology (FNAC) in the diagnosis of subcutaneous cysticercosis. FNAC was performed using 23/21 gauge needle and 20 ml disposable plastic syringe fitted to a specially designed holder. Total, 66 cases were diagnosed to have cysticercosis, some rare sites were also aspirated like midline neck swelling & breast. In 48 cases (72.72%) actual parasitic structures, like fragment of the wall or tegument of parasite were demonstrated. In rest of cases inflammatory cell and eosinophils were seen. if the FNAC is done by trained cytopathologist with thin needle and with precautions, then it is quite safe and cost effective method, thereby eliminating the need of histopathological examination.