The intramolecular Dötz benzannulation with alkyne-tethered aryloxy Fischer carbenes has been applied to synthesize a nine membered diaryl ether linked macrocyclic library. Insilico tools, that is, shape space analysis was used to assess the diversity of the library, and polar surface area (PSA) of the compounds were deduced to understand the range of their surface electrostatic potential. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Subhabrata Sen

Chemistry

(SoNS) School of Natural Sciences

Mamidala R.

Gundla R.

Charya M.T.

<p>Shiv Nadar University is a comprehensive, multidisciplinary, research-focused, and student-centric University offering a full range of academic programs at the undergraduate, postgraduate and doctoral level. With state-of-the-art infrastructure, the University comprises of academic wings, sophisticated labs, international standard sports facilities, amphitheaters, auditorium, conference rooms and smart classrooms. The University&rsquo;s goal is to become internationally recognized for the quality of its research and creative endeavors and their applicability to improving quality of life, generating new insights and expanding the boundaries of human knowledge creativity. Committed to excellence in teaching, research and service, the University aims to serve the higher education needs of India and the world beyond.</p>

Shiv Nadar University

Asian Journal of Organic Chemistry

Nature Chemical Biology

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

Organic & Biomolecular Chemistry

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds

MedChemComm

Emac – a comparative index for the assessment of macrocyclization efficiency

European Journal of Organic Chemistry

Biologically Active Macrocyclic Compounds - from Natural Products to Diversity-Oriented Synthesis

Journal of Medicinal Chemistry

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation