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Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation
, Mamidala R., Gundla R., Charya M.T.
Published in Wiley-VCH Verlag
Volume: 2
Issue: 10
Pages: 862 - 868
The intramolecular Dötz benzannulation with alkyne-tethered aryloxy Fischer carbenes has been applied to synthesize a nine membered diaryl ether linked macrocyclic library. Insilico tools, that is, shape space analysis was used to assess the diversity of the library, and polar surface area (PSA) of the compounds were deduced to understand the range of their surface electrostatic potential. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Published in Wiley-VCH Verlag
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