<p>Shiv Nadar University is a comprehensive, multidisciplinary, research-focused, and student-centric University offering a full range of academic programs at the undergraduate, postgraduate and doctoral level. With state-of-the-art infrastructure, the University comprises of academic wings, sophisticated labs, international standard sports facilities, amphitheaters, auditorium, conference rooms and smart classrooms. The University&rsquo;s goal is to become internationally recognized for the quality of its research and creative endeavors and their applicability to improving quality of life, generating new insights and expanding the boundaries of human knowledge creativity. Committed to excellence in teaching, research and service, the University aims to serve the higher education needs of India and the world beyond.</p>

Shiv Nadar University

(SoNS) School of Natural Sciences

Turning light: A crystalline fullerene material based on H-bonding interactions exhibits highly polarized fluorescence emission, whose angle of polarization can be turned using light (see picture). This process can be used to write optical information onto the material, which can be read through the polarization component of the luminescence emitted by the material. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

World University root node

Chemistry

Angewandte Chemie - International Edition

Controlling the emission polarization from single crystals using light: Towards photopolic materials

Two particles that are just shy of binding may develop an infinite number of shallow bound states when a third particle is added. This counter intuitive quantum mechanical result was first predicted by V. Efimov for identical bosons interacting with a short-range pair-wise potential. The so-called Efimov effect persists even for non-identical particles, provided at least two of the three bonds are almost bound. The Efimov effect has recently been verified experimentally using ultra-cold atoms. In this article, we explain the origin of this effect using only elementary quantum mechanics and summarize the experimental evidence for the Efimov effect. A new, simple derivation for the number of Efimov states is given in the Appendix.

Physics

American Journal of Physics

An elementary exposition of the Efimov effect

Pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione or diketopyrrolopyrrole (DPP) is a useful electron-withdrawing fused aromatic moiety for the preparation of donor-acceptor polymers as active semiconductors for organic electronics. This study uses a DPP-furan-containing building block, 3,6-di(furan-2-yl)pyrrolo[3,4- c]pyrrole-1,4(2H,5H)-dione (DBF), to couple with a 2,2′-bithiophene unit, forming a new donor-acceptor copolymer, PDBFBT. Compared to its structural analogue, 3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione (DBT), DBF is found to cause blue shifts of the absorption spectra both in solution and in thin films and a slight reduction of the highest occupied molecular orbital (HOMO) energy level of the resulting PDBFBT. Despite the fact that its thin films are less crystalline and have a rather disordered chain orientation in the crystalline domains, PDBFBT shows very high hole mobility up to 1.54 cm 2 V-1 s-1 in bottom-gate, top-contact organic thin film transistors. © 2011 The Royal Society of Chemistry.

Fulltext

Journal of Materials Chemistry

3,6-Di(furan-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione and bithiophene copolymer with rather disordered chain orientation showing high mobility in organic thin film transistors

We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled d-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region. © The Royal Society of Chemistry 2011.

Organic and Biomolecular Chemistry

Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

A $\pi$-electron rich supramolecular polymer as an efficient fluorescent sensor for electron deficient nitroaromatic explosives has been synthesized and the role of H-bonding in dramatic amplification of sensitivity/fluorescence quenching efficiency in the solid state has been established. {\textcopyright} The Royal Society of Chemistry 2011.

Chemical Communications

Supramolecular polymer for explosives sensing: Role of H-bonding in enhancement of sensitivity in the solid state

A one-pot procedure for the efficient hydroazidation of alkenes involving hydroboration with catecholborane followed by reaction with benzenesulfonyl azide in the presence of a radical initiator is described. The regioselectivity is controlled by the hydroboration step and corresponds in most cases to an anti-Markovnikov regioselectivity. This procedure is applicable to a wide range of alkenes and gives excellent results with 1,2-disubstituted and trisubstituted alkenes. {\textcopyright} 2011 American Chemical Society.

Journal of the American Chemical Society

A radical procedure for the anti-markovnikov hydroazidation of alkenes

Adhesive forces at endothelial cell-cell borders maintain vascular integrity. cAMP enhances barrier properties and controls cellular processes through protein kinase A bound to A-kinase anchoring proteins (AKAPs). It also activates exchange protein directly activated by cAMP (Epac1), an exchange factor for Ras-related protein 1 (Rap1) GTPases that promotes cadherin- and integrin-mediated adhesion through effects on the actin cytoskeleton. We demonstrate that AKAP9 facilitates the microtubule polymerization rate in endothelial cells, interacts with Epac1, and is required for Epac1-stimulated microtubule growth. AKAP9 is not required for maintaining barrier properties under steady-state conditions. Rather, it is essential when the cell is challenged to make new adhesive contacts, as is the case when Epac activation enhances barrier function through a mechanism that, surprisingly, requires integrin adhesion at cell-cell contacts. In the present study, defects in Epac-induced responses in AKAP9-silenced cells were evident despite an intact Epac-induced increase in Rap activation, cortical actin, and vascular endothelial-cadherin adhesion. We describe a pathway that integrates Epac-mediated signals with AKAP9-dependent microtubule dynamics to coordinate integrins at lateral borders. © 2011 by The American Society of Hematology.

Life Sciences

Blood

AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties

VLF chorus emissions recorded at Indian Antarctic station, Maitri (Lat = 70.46’CS, Long = 11.50’CE, L = 4.5) during a geomagnetic quiet period on 3 Feb. 2001 is reported. The detailed spectral analysis of recorded chorus emissions shows that each chorus element originates from the upper edge of the underlying hiss band. The observed mean chorus element parameters are as follows: lower band frequency fmin = 3.1 kHz, upper band frequency ƒUB = 4.8 kHz, frequency sweep rate df/dt = 2.1 kHz/s and repetition period T = 1 s. To explain the observed dynamic spectra of these chorus emissions, a possible generation mechanism is presented based on the recent nonlinear theory. On the basis of this theory, frequency sweep rate of chorus emission is computed and compared with that of our experimentally observed values, which shows, in general, good agreements. © 2011 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.

Advances in Geosciences: Volume 27: Solar Terrestrial (ST)

Nonlinear generation mechanism of VLF chorus emissions observed at Antarctica during a quiet period

The ErbB receptor family member ErbB3 has been implicated in breast cancer growth, but it has yet to be determined whether its disruption is therapeutically valuable. In a mouse model of mammary carcinoma driven by the polyomavirus middle T (PyVmT) oncogene, the ErbB2 tyrosine kinase inhibitor lapatinib reduced the activation of ErbB3 and Akt as well as tumor cell growth. In this phosphatidylinositol-3 kinase (PI3K)-dependent tumor model, ErbB2 is part of a complex containing PyVmT, p85 (PI3K), and ErbB3, that is disrupted by treatment with lapatinib. Thus, full engagement of PI3K/Akt by ErbB2 in this oncogene-induced mouse tumor model may involve its ability to dimerize with and phosphorylate ErbB3, which itself directly binds PI3K. In this article, we report that ErbB3 is critical for PI3K/Akt-driven tumor formation triggered by the PyVmT oncogene. Tissue-specific, Cre-mediated deletion of ErbB3 reduced Akt phosphorylation, primary tumor growth, and pulmonary metastasis. Furthermore, EZN-3920, a chemically stabilized antisense oligonucleotide that targets the ErbB3 mRNA in vivo, produced similar effects while causing no toxicity in the mouse model. Our findings offer further preclinical evidence that ErbB3 ablation may be therapeutically effective in tumors where ErbB3 engages PI3K/Akt signaling. ©2011 AACR.

Cancer Research

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) axis regulates essential cellular functions including cell survival, proliferation, metabolism, migration, and angiogenesis. The PI3K pathway is activated in human cancers by mutation, amplification, and deletion of genes encoding components of this pathway. The critical role of PI3K in cancer has led to the development of drugs targeting the effector mechanisms of this signaling network. Recent studies have shown that inhibition at multiple levels of the PI3K pathway results in FOXOdependent feedback reactivation of several receptor tyrosine kinases (RTKs) which, in turn, limit the sustained inhibition of this pathway and attenuates the action of therapeutic antagonists. This suggests that if used as single agents, PI3K pathway inhibitors may have limited clinical activity. We propose herein that to successfully target the output of the PI3K pathway in cancer cells, combination therapies that hinder these compensatory mechanisms should be used. Thus, combination therapies that target RTKs, PI3K, and mTOR activities may be required to maximize the clinical benefit derived from treatment with these inhibitors. © Garrett et al.