<p>Shiv Nadar University is a comprehensive, multidisciplinary, research-focused, and student-centric University offering a full range of academic programs at the undergraduate, postgraduate and doctoral level. With state-of-the-art infrastructure, the University comprises of academic wings, sophisticated labs, international standard sports facilities, amphitheaters, auditorium, conference rooms and smart classrooms. The University&rsquo;s goal is to become internationally recognized for the quality of its research and creative endeavors and their applicability to improving quality of life, generating new insights and expanding the boundaries of human knowledge creativity. Committed to excellence in teaching, research and service, the University aims to serve the higher education needs of India and the world beyond.</p>

Shiv Nadar University

(SoNS) School of Natural Sciences

In India, nurses wear white coats over their uniform. In this small study, patches of polyester and polyester cotton blend fabrics were attached to the white coats of nurses and sampled for contamination after one shift. Results showed that microbial adhesion is influenced by fabric type, with the microbial load on the polyester cotton blend fabric being 60\% higher than that on the polyester fabric. Further studies need to be conducted to establish the correlation between fabric properties and microbial contamination. © 2016 The Healthcare Infection Society

World University root node

Life Sciences

Journal of Hospital Infection

Bacterial contamination of nurses’ white coats made from polyester and polyester cotton blend fabrics

Traumatic brain injury (TBI) imposes horrendous neurophysiological alterations leading to most devastating forms of neuro-disability. Which includes impaired cognition, distorted locomotors activity and psychosomatic disability in both youths and adults. Emerging evidence from recent studies has identified mesenchymal stem cells (MSCs) as one of the promising category of stem cells having excellent neuroregenerative capability in TBI victims. Some of the clinical and animal studies reported that MSCs transplantation could cure neuronal damage as well as improve cognitive and locomotors behaviors in TBI. However, mechanism behind their broad spectrum neuroregenerative potential in TBI has not been reviewed yet. Therefore, in the present article, we present a comprehensive data on the important attributes of MSCs, such as neuro- transdifferentiation, neuroprotection, axonal repair and plasticity, maintenance of blood-brain integrity, reduction of reactive oxygen species (ROS) and immunomodulation. We have reviewed in detail the crucial neurogenic capabilities of MSCs in vivo and provided consolidated knowledge regarding their cellular remodeling in TBI for future therapeutic implications. © 2016 Bentham Science Publishers.

Current Stem Cell Research and Therapy

Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury

In this paper, we discuss the parametric symmetries in different exactly solvable systems characterized by real or complex PT symmetric potentials. We focus our attention on the conventional potentials such as the generalized Pöschl Teller (GPT), Scarf-I, and PT symmetric Scarf-II which are invariant under certain parametric transformations. The resulting set of potentials is shown to yield a completely different behavior of the bound state solutions. Further, the supersymmetric partner potentials acquire different forms under such parametric transformations leading to new sets of exactly solvable real and PT symmetric complex potentials. These potentials are also observed to be shape invariant (SI) in nature.We subsequently take up a study of the newly discovered rationally extended SI potentials, corresponding to the above mentioned conventional potentials, whose bound state solutions are associated with the exceptional orthogonal polynomials (EOPs).We discuss the transformations of the corresponding Casimir operator employing the properties of the so(2,1) algebra.

Physics

Fulltext

Journal of Mathematical Physics

Parametric symmetries in exactly solvable real and PT symmetric complex potentials

Boron atomic clusters show several interesting and unusual size-dependent features due to the small covalent radius, electron deficiency, and higher coordination number of boron as compared to carbon. These include aromaticity and a diverse array of structures such as quasi-planar, ring or tubular shaped, and fullerene-like. In the present work, we have analyzed features of the computed electron density distributions of small boron clusters having up to 11 boron atoms, and investigated the effect of doping with C, P, Al, Si, and Zn atoms on their structural and physical properties, in order to understand the bonding characteristics and discern trends in bonding and stability. We find that in general there are covalent bonds as well as delocalized charge distribution in these clusters. We associate the strong stability of some of these planar/quasiplanar disc-type clusters with the electronic shell closing with effectively twelve delocalized valence electrons using a disc-shaped jellium model. B10, B7P, and B8Si, in particular, are found to be exceptional with very large gaps between the highest occupied molecular orbital and the lowest unoccupied molecular orbital, and these are suggested to be magic clusters. © 2016 The Royal Swedish Academy of Sciences.

Center for Informatics

Chemistry

Physica Scripta

Analysis of the electron density features of small boron clusters and the effects of doping with C, P, Al, Si, and Zn: Magic B7P and B8Si clusters

An exceptional oxone mediated tandem transformation of 2-aminobenzylamines to 2-substituted benzimidazoles is reported. It occurs at room temperature with aromatic, heteroaromatic, and aliphatic aldehydes. In this reaction initial condensation of 2-aminobenzylamine with appropriate aldehydes afforded a tetrahydroquinazoline intermediate which underwent oxone-mediated ring distortion to afford the desired compounds in moderate to excellent yields. © 2016 American Chemical Society.

Organic Letters

Accessing Benzimidazoles via a Ring Distortion Strategy: An Oxone Mediated Tandem Reaction of 2-Aminobenzylamines

In this paper, we consider the rational extensions of two different classes of PT symmetric complex potentials namely the asymptotically vanishing Scarf II and asymptotically non-vanishing Rosen–Morse II [ RM-II] and obtain the accompanying bound state eigenfunctions in terms of the exceptional Xm Jacobi polynomials and a certain class of orthogonal polynomials. By considering the asymptotic behavior of the exceptional polynomials, we also derive the reflection and transmission amplitudes for them and discuss the various novel properties of the corresponding amplitudes. © 2016 Elsevier Inc.

Annals of Physics

Scattering amplitudes for the rationally extended PT symmetric complex potentials

Hydrogen sulfide (H2S) has been recognized as one of most important gaseous signaling molecules mediated by a variety of physiological and pathological processes. Yet, its functions remain largely elusive due to the lack of potent monitoring methods. Hereby this issue is addressed with a powerful new platform - dye-assembled upconversion nanoparticles (UCNPs). A series of chromophores with different absorption bands and fast responses towards H2S is combined with UCNPs and results in a library of H2S sensors with responsive emission signals ranging from the visible to the near-infrared (NIR) region. These nanoprobes demonstrate highly selective and rapid responses to H2S in vitro and in cells. Furthermore, H2S levels in blood can be detected using the developed nanoprobes. Hence the reported H2S sensing platform can serve as a powerful diagnostic tool to research H2S functions and to investigate H2S-related diseases. The request of powerful sensor probes for environmental and bioimaging fields has attracted intensive and enthusiastic research during the past decades. Hereby a new dye-assembled H2S sensing platform - dye-assembled upconversion nanoparticles (UCNPs) - is designed. These probes with emission spectra ranging from visible to near-infrared (NIR) are applicable for H2S detection in cells and mice serum. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Advanced Functional Materials

Development of a Highly Selective, Sensitive, and Fast Response Upconversion Luminescent Platform for Hydrogen Sulfide Detection

Theory predicts herein enzymatic activity from scratch. We show that molecular dynamics (MD) simulations and quantum-mechanical/molecular mechanics (QM/MM) calculations of the fatty acid hydroxylase P450 BM3 predict the binding mechanism of the fatty acid substrate and its enantio/regioselective hydroxylation by the active species of the enzyme, Compound I. The MD simulations show that the substrate's entrance involves hydrogen-bonding interactions with Pro25, Glu43, and Leu188, which induce a huge conformational rearrangement that closes the substrate channel by pulling together the A helix and the β1 sheet to the F/G loop. In turn, at the bottom of the substrate's channel, residue Phe87 controls the regioselectivity by causing the substrate's chain to curl up and juxtapose its CH2 positions ω-1/ω-2/ω-3 to Compound I while preventing access to the endmost position, ω-CH3. Phe87 also controls the stereoselectivity by the enantioselective steric blocking of the pro-S C-H bond, thus preferring R hydroxylation. Indeed, the MD simulations of the mutant Phe87Ala predict predominant ω hydroxylation. These findings, which go well beyond the X-ray structural data, demonstrate the predictive power of theory and its insight, which can potentially be used as a partner of experiment for eventual engineering of P450 BM3 with site-selective C-H functionalization capabilities. © 2015 American Chemical Society.

Journal of the American Chemical Society

Molecular Dynamics and QM/MM Calculations Predict the Substrate-Induced Gating of Cytochrome P450 BM3 and the Regio- and Stereoselectivity of Fatty Acid Hydroxylation

Scientific Reports

Erratum: Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors (Scientific Reports (2016) 6 (26603) DOI: 10.1038/srep26603)

Contrary to common expectation, a left-sneutrino can occasionally be the lightest supersymmetric particle. This has important implications in both collider and dark matter studies. We show that same-sign tri-lepton (SS3L) events at the Large Hadron Collider, with any lepton having opposite sign vetoed, distinguish such scenarios, up to gluino masses exceeding 2 TeV. The jets+. MET signal rate is somewhat suppressed in this case, thus enhancing the scope of leptonic signals.