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Regulating signal enhancement with coordination-coupled deprotonation of a hydrazone switch
Foy J.T., , Aprahamian I.
Published in Royal Society of Chemistry
Volume: 6
Issue: 1
Pages: 209 - 213
Proton relay plays an important role in many biocatalytic pathways. In order to mimic such processes in the context of molecular switches, we developed coordination-coupled deprotonation (CCD) driven signaling and signal enhancement sequences. This was accomplished by using the zinc(ii)-initiated CCD of a hydrazone switch to instigate an acid catalyzed imine bond hydrolysis that separates a quencher from a fluorophore thus leading to emission amplification. Because CCD is a reversible process, we were able to show that the catalysis can be regulated and turned "on" and "off" using a metalation/demetalation cycle. This journal is © The Royal Society of Chemistry.
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Published in Royal Society of Chemistry
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