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Progress in development of vaccine against Hyalomma anatolicum: Anatolicum-Indian scenario
S. Ghosh, D. Ray D., Vanlahmuaka, G. Das, N. Singh K., , P. Azhahianambi
Published in
Volume: 26
Issue: SUPPL.6
Hyalomma anatolicum anatolicum, a three host tick vector transmitting the causative agent of bovine tropical theileriosis, is widely distributedthroughout India. As acomponent of integratedcontrol measures against the tick vector, attempts have been made to identify candidate protein molecules for development of an anti-tick vaccine in the different stages of this tick species. By strategic methods of isolation of the targeted molecules using affinity purification of proteins showing reactivity with immunoglobulins of animals previously immunized with different sources of tick antigen, six proteins were isolated in a significantly pure form. The recovery percentage of the candidate proteins was very low in the range of 1.8-8.0%. The protective potentiality of the antigens was tested in immunization and challenge trials and maximum potentialwas observed in the proteins isolated from total larval extracts, nymphal extracts and in larval glycoprotein. One of the antigens with a molecular weight of 37 kDa isolated from larvae of H. a. anatolicumwas found to have some adverse effect on development of Theileria annulata in the vector tick. The progress in the development of immunoprophylactic measures against H. a. anatolicum is discussed. {\textcopyright} 2008 Elsevier Ltd.
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