Antibiotic drug resistance is a global crisis today. The deleterious impact of this crisis is acting relatively in higher degrees in poor nations compared to developed countries in the world. Low economy and irrational perspective on medical practice are accelerating the development of drug resistance, leading the population in more economically challenged situations. This article discusses current situations, expresses opinions and views on the self-reinforcement process in the emergence and development of drug resistance. © Indian Academy of Sciences.