Monitoring and performing agricultural practices over a large spatial coverage often require advanced and accurate positional information in order to optimize the operational costs as well as reduce estimated time of completion. Agricultural practices with large farms are challenging to operate from remote sensing until accurate positional information is not available, which necessitates the use of Global Positioning System (GPS) for acquiring sample position using Global Navigation Satellite System (GNSSs). Thus, development of positional accuracies with the help of GNSS signals has boosted up the involvement of GPS-based instruments in precision agriculture (PA). It has opened the wide door for the implementation of GPS in the PA, as per user needs and requirements. Furthermore, GPS instruments have been evolved with time, and nowadays advanced GPS instruments are in the market and can be operated via mobile with any operating systems, i.e., iOS, Android, or Windows. Availability of GPS signals in several instruments or equipment has been looked as the market opportunity and increasing trends in PA resulting in innovations of techniques for route optimization for optimal use of fertilizer spray and related activities in agricultural practices transforming to new look as SMART farming. The main conclusion of this chapter is to make aware about the growing GPS applications and evolution of SMART farming, that is, wisely employing Internet for precision applications. © 2021 Elsevier Inc. All rights reserved.