In this paper, a complete transmitter has been designed using low-voltage differential signaling (LVDS) technology. It is a new analog technology based on the serial I/O interface data communications. The complete transmitter circuit consists of driver, cascode current mirror circuit, pseudo random binary sequence (PRBS), and electrostatic discharge (ESD) pad. Here, transmitter is designed initially, and its biasing has been done using cascode current mirror. The layout parameter variation approach has been used to design ESD protection circuit for transmitter. An effort was made to reduce the parasitic capacitance and parasitic resistance. It helps to improve the performance of transmitter and reducing electrostatic discharge issues. The complete system has been designed using 0.18 μm CMOS technology at 1.8 V. The data rate of 2 Gbps and power consumption of 6.3 mW has been achieved using Cadence virtuoso PDK of Silatera Malaysia. © 2016 IEEE.