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Visualization and quantification of Plasmodium falciparum intraerythrocytic merozoites
Garg S., Agarwal S., Dabral S., Kumar N., , Singh S.
Published in Springer Netherlands
Volume: 9
Pages: 23 - 26
Malaria, a leading parasitic killer, is caused by Plasmodium spp. The pathology of the disease starts when Plasmodium merozoites infect erythrocytes to form rings, that matures through a large trophozoite form and develop into schizonts containing multiple merozoites. The number of intra-erythrocytic merozoites is a key-determining factor for multiplication rate of the parasite. Counting of intraerythrocytic merozoites by classical 2-D microscopy method is error prone due to insufficient representation of merozoite in one optical plane of a schizont. Here, we report an alternative 3-D microscopy based automated method for counting of intraerythrocytic merozoites in entire volume of schizont. This method offers a considerable amount of advantages in terms of both, ease and accuracy. © 2015, Springer Science+Business Media Dordrecht.
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Published in Springer Netherlands
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