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Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection
, K.K. Maiti, K.-S. Soh, X. Liao, M. Vendrell, U.S. Dinish, S.-W. Yun, R. Bhuvaneswari, H. Kim, S. RautelaShow More
Published in
PMID: 21591030
Volume: 50
Issue: 27
Pages: 6089 - 6092
Of good report: Synthesis and screening of an 80-member tricarbocyanine library identified CyNAMLA-381 as a near-IR surface-enhanced Raman spectroscopy (SERS) reporter with good signal stability and higher sensitivity than the standard. Encapsulation of CyNAMLA-381 on gold nanoparticles and conjugation to an antibody afforded SERS nanotags with excellent sensitivity, stability, and tumor specificity in xenograft models (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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