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Transition-Metal-Free Terminal Alkyne Addition to Isatins
Kalyan Dhara, , Tridev Ghosh, Jyotirmayee Dash
Published in
Volume: 48
Issue: 23
Pages: 4226 - 4268
A 'direct' alkynylation of isatins, which uses potassium tert-butoxide to provide the desired 3-hydroxy-3-ethynyl-2-oxindoles in good to high yields, is reported. This protocol proceeds smoothly for both electron-rich and electron-deficient alkynes in comparable reaction rates and does not require any specially design ligand or expensive transition-metal catalysts.
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