Header menu link for other important links
Transition-metal-free hydration of nitriles using potassium tert -butoxide under anhydrous conditions
Ganesh Midya Chandra, , Subhadip Maiti, Jyotirmayee Dash
Published in
Volume: 80
Issue: 8
Pages: 4148 - 4151
Potassium tert-butoxide acts as a nucleophilic oxygen source during the hydration of nitriles to give the corresponding amides under anhydrous conditions. The reaction proceeds smoothly for a broad range of substrates under mild conditions, providing an efficient and economically affordable synthetic route to the amides in excellent yields. This protocol does not need any transition-metal catalyst or any special experimental setup and is easily scalable to bulk scale synthesis. A single-electron-transfer radical mechanism as well as an ionic mechanism have been proposed for the hydration process.
About the journal
Published in
Open Access
Impact factor