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Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes
Published in Georg Thieme Verlag
Volume: 48
Issue: 9
Pages: 1389 - 1398
We have demonstrated a facile synthesis of diversely substituted quinazolines and 3,4-dihydroquinazolines through the o-iodoxybenzoic acid (IBX) mediated tandem reaction of readily available o-aminobenzylamine and aldehydes. The yield of the reactions generally ranged from 70\% to 95\%. This mild protocol provides an efficient strategy toward the synthesis of these classes of heterocycles. © Georg Thieme Verlag Stuttgart.
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Published in Georg Thieme Verlag
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