Header menu link for other important links
Synthesis and biological evaluation of novel quinazoline-sulfonamides as anti-cancer agents
Poudapally S., Battu S., Velatooru L.R., Bethu M.S., Janapala V.R., Sharma S., , Pottabathini N., Iska V.B.R., Katangoor V.
Published in Elsevier Ltd
PMID: 28351589
Volume: 27
Issue: 9
Pages: 1923 - 1928
A robust economic approach to N-(quinazoline-4-yl)sulfonamides was developed and synthesized different aryl, hetero aryl, alkyl and cyclopropyl sulfonamides in excellent yields. All the compounds were evaluated for cytotoxic affinity to SKOV3, DU145, THP1, U937, and COLO205 cell lines. Interesting to find that the bulkiness of substituent at C-2 position of quinazoline forces the molecule to flip around in order to bind in the active site, when compared to the binding preference of previously known quinazoline compounds. Among the 21 compounds synthesized 2b, 2d, 2e, 2h, 2i, 3c, 3d, 3f, 3g and 3h found to be active on all the cell lines tested with IC50 values <10 µg/mL. Performed docking simulations to understand the binding preference of various C-2 substituted quinazoline sulfonamides. © 2017 Elsevier Ltd
About the journal
Published in Elsevier Ltd
Open Access
Impact factor