The Bures distance holds a special place among various distance measures due to its several distinguishing features and has applications in diverse problems in quantum information theory. It is related to fidelity, and among other things, it serves as a bona fide measure for quantifying the separability of quantum states. In this work, we calculate exact analytical results for the mean root fidelity and mean-square Bures distance between a fixed density matrix and a random density matrix and also between two random density matrices. In the course of derivation, we also obtain the spectral density for the product of the above pairs of density matrices. We corroborate our analytical results using Monte Carlo simulations. Moreover, we compare these results with the mean-square Bures distance between reduced density matrices generated using coupled kicked tops and find very good agreement. © 2021 American Physical Society.