Header menu link for other important links
Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage during Acute Inflammation
Ahmed N., , Guengerich F.P., Chowdhury G.
Published in American Chemical Society
PMID: 32894672
Volume: 33
Issue: 10
Pages: 2668 - 2674
Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current coronavirus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other thiols in neutralizing the effect of peroxynitrite-mediated DNA damage through stable GSH-DNA adduct formation. Our observation supports the use of thiol supplements as a potential therapeutic strategy against severe COVID-19 cases and a Phase II (NCT04374461) open-label clinical trial launched in early May 2020 by the Memorial Sloan Kettering Cancer Center. © 2020 American Chemical Society.
About the journal
Published in American Chemical Society
Open Access
Impact factor