Presently, to enhance the thermal efficiency of a gas turbine power plant, turbine inlet air cooling (TIAC) is the widely used technique. The conventional refrigeration methods like vapor compression refrigeration and evaporative cooling need electric power, hence absorption and adsorption refrigeration systems are attractive options as they can be powered using the waste heat energy of the exhaust gases. Adsorption system has advantages over absorption system like scalability, requirement of lower heat source temperature, absence of corrosion and crystallization. This paper focuses on the thermodynamic analysis of waste heat powered adsorption chiller used for the cooling of intake air to enhance the net power output of the gas turbine power plant. This paper also presents a comparative analysis of the vapor-adsorption cycle-based TIAC system for four different refrigerants viz. HFC-134a, carbon dioxide, ethanol and ammonia with the motive of finding a substitute refrigerant for HFC-134a which has a high global warming potential (GWP). The adsorption chiller is mathematically modeled in MATLAB with activated carbon as the adsorbent and each one of carbon dioxide, ethanol and ammonia as the adsorbate. The variation of the coefficient of performance (COP) and specific cooling effect (SCE) with varying adsorption temperatures is presented for each pair. The net power output and primary energy rate (PER) improvement of the gas turbine power plant at different ambient temperatures are also discussed. It is observed that ammonia can improve the power plant performance significantly better compared to the other three refrigerants at ambient temperatures less than 40°C. © 2018 World Scientific Publishing Company.