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N1- and N3-Arylations of Hydantoins Employing Diaryliodonium Salts via Copper(I) Catalysis at Room Temperature
Abha Saikia R., Barman D., Dutta A., Jyoti Thakur A.
Published in Wiley-VCH Verlag
Volume: 2021
Issue: 3
Pages: 400 - 410
Copper(I)-catalyzed N-arylation (both N1- and N3-) of hydantoins with diaryliodonium salts as aryl partners at room temperature is reported. The transformation allows diverse scopes on both hydantoins and diaryliodonium salts delivering functionalized N3-arylated products under mild reaction conditions. The presence of hydrogens at C5- and N1- position of the hydantoin does not lead to other side products. Chiral hydantoins can also be synthesized via this methodology. Sterically complicated ortho-substituted diaryliodonium salts are tolerated and delivered challenging ortho-arylated products. In addition, this strategy can also be effectively extended to N1-arylation of hydantoins. © 2020 Wiley-VCH GmbH
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Published in Wiley-VCH Verlag
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