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N-heterocyclic carbene catalyzed homoenolate-addition reaction of enals and nitroalkenes: Asymmetric synthesis of 5-carbon-synthon δ-nitroesters
B. Maji, L. Ji, S. Wang, S. Vedachalam, , X.-W. Liu
Published in
Volume: 51
Issue: 33
Pages: 8276 - 8280
Synthesizing synthons: The highly enantioselective title reaction is described. It employs catalytic amounts of N-heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ-nitroesters via homoenolate intermediates (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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