Synthesizing synthons: The highly enantioselective title reaction is described. It employs catalytic amounts of N-heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ-nitroesters via homoenolate intermediates (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Rakesh Ganguly

SNU Management

B. Maji

L. Ji

S. Wang

S. Vedachalam

X.-W. Liu

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Shiv Nadar University

Angewandte Chemie - International Edition

N-heterocyclic carbene catalyzed homoenolate-addition reaction of enals and nitroalkenes: Asymmetric synthesis of 5-carbon-synthon δ-nitroesters