SERS nanotags have been prepared to accomplish the multiplex detection of cancer cells. Herein we evaluated the adequacy of lipoic acid-containing cyanine derivatives (Cy3LA and Cy5LA) to function as multiplex partners with a triphenylmethine Raman reporter (B2LA) under a single excitation wavelength. SERS experiments enabled the multiplex recognition of two different cancer cells with antibody-conjugated nanotags that were derivatized with optimized cyanine and triphenylmethine reporters. © 2011 The Royal Society of Chemistry.

Animesh Samanta

Chemistry

(SoNS) School of Natural Sciences

K.K. Maiti

M. Vendrell

K.-S. Soh

M. Olivo

Y.-T. Chang

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Shiv Nadar University

Chemical Communications

Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters