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Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase
W.X. Koh, L. Coppo, , A. Holmgren, W.K. Leong
Published in Elsevier B.V.
Volume: 943
Ferrocenyl and ruthenocenyl derivatives of ebselen are found to be competitive inhibitors of mammalian TrxR, with IC50 of 4.2 ± 0.3 and 2.5 ± 0.3 µM, respectively. The inhibition of TrxR is selective over GR, and in the presence of excess GSH. They exhibit lower Km values than ebselen and the natural substrate, Trx. © 2021 Elsevier B.V.
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Published in Elsevier B.V.
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