Header menu link for other important links
Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays
Muthukumarasamy K.M., Handore K.L., Kakade D.N., Shinde M.V., Ranjan S., Kumar N., , Sachidanandan C., Reddy D.S.
Published in Royal Society of Chemistry
PMID: 26483278
Volume: 14
Issue: 5
Pages: 1569 - 1578
Noreremophilanes are a rare class of cis-hydrindanes produced by genus Ligularia herbaceous plants which are known to exhibit interesting biological activities. We synthesized cis-hydrindanes based on a naturally occurring noreremophilane scaffold using a Diels-Alder/aldol sequence and screened them for multiple biological activities using high-content zebrafish embryonic development assays. We discovered a noreremophilane that has strong anti-angiogenic effects on the developing zebrafish embryos as well as on tumor-induced angiogenesis in a zebrafish xenograft model. We synthesized several derivatives of this class of noreremophilanes and performed structure-activity relationship studies in zebrafish to identify more potent and less toxic analogs of the original structure. © The Royal Society of Chemistry 2016.
About the journal
Published in Royal Society of Chemistry
Open Access
Impact factor