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Hg-C bond protonolysis by a functional model of bacterial enzyme organomercurial lyase MerB
Karri R., Das R., Rai R.K., Gopalakrishnan A., Roy G.
Published in Royal Society of Chemistry
PMID: 32558833
Volume: 56
Issue: 65
Pages: 9280 - 9283
Herein, we report a novel synthetic compound 1, having a highly nucleophilic selenolate (Se-) moiety and a thiol (-SH) functional group, which showed efficient Hg-C bond protonolysis of various R-Hg-X molecules including neurotoxic methylmercury and thimerosal, via direct -SH proton transfer to the highly activated C-atom of a departed R group with low activation energy barrier at room temperature (21 °C), in the absence of any external proton source and, thus, acts as a functional model of MerB. This journal is © The Royal Society of Chemistry.
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Published in Royal Society of Chemistry
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