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Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery
S. Han, , X. Xie, L. Huang, J. Peng, S.J. Park, D.B.L. Teh, Y. Choi, Y.-T. Chang, A.H. AllShow More
Published in Wiley-VCH Verlag
PMID: 28295739
Volume: 29
Issue: 18
Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides in biological systems. Herein, a method to robustly disperse upconversion nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprising hairpin-DNA-modified gold nanoparticles is presented. This approach imparts the upconversion nanoprobes with excellent biocompatibility and circumvents the problem of particle agglomeration. By combining single-band anti-Stokes near-infrared emission and the photothermal effect mediated by the coupling of gold to upconversion nanoparticles, a simple, versatile nanoparticulate system for simultaneous deep-tissue imaging and drug molecule release in vivo is demonstrated. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Published in Wiley-VCH Verlag
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