Proper bonding technique is investigated to achieve leakage-free surface-driven capillary flow in polymethylmethacrylate (PMMA) microfluidic devices. SU-8-based silicon stamp is fabricated by maskless lithography. This stamp is used to produce PMMA microchannel structure by hot embossing lithography. A direct bonding technique is mainly employed for leakage-free sealing inside PMMA microfluidic devices. The effect of surface wettability on surface-driven capillary flow is also investigated in PMMA microfluidic devices. The separation of polystyrene microparticles in PMMA laboratory-on-a-chip systems is investigated with the reduction of separation time by air dielectric barrier discharge (DBD) plasma processing of channel surfaces. This study is useful to fabricate the microfluidic laboratory-on-a-chip systems and to understand the surface-driven capillary flow. © 2015 World Scientific Publishing Company.

Susanta Sinha Roy

Physics

(SoNS) School of Natural Sciences

Mukhopadhyay S.

Banerjee J.P.

Mathur A.

Tweedie M.

McLaughlin J.A.

<p>Shiv Nadar University is a comprehensive, multidisciplinary, research-focused, and student-centric University offering a full range of academic programs at the undergraduate, postgraduate and doctoral level. With state-of-the-art infrastructure, the University comprises of academic wings, sophisticated labs, international standard sports facilities, amphitheaters, auditorium, conference rooms and smart classrooms. The University&rsquo;s goal is to become internationally recognized for the quality of its research and creative endeavors and their applicability to improving quality of life, generating new insights and expanding the boundaries of human knowledge creativity. Committed to excellence in teaching, research and service, the University aims to serve the higher education needs of India and the world beyond.</p>

Shiv Nadar University

Experimental studies of surface-driven capillary flow in pmma microfluidic devices prepared by direct bonding technique and passive separation of microparticles in microfluidic laboratory-on-a-chip systems

Surface Review and Letters

In this research paper, in total 212 individual leakage-free Polymethylmethacrylate (PMMA) microfluidic devices are fabricated by maskless lithography, hot embossing lithography and direct bonding technique. The effect of channel aspect ratio on dyed water flow is investigated using these microfluidic devices. Experimental studies show that the dyed water flow is faster on the surface of higher wettability. The effect of capillary pressure on dyed water flow is studied in the fabricated PMMA microfluidic devices. According to the experimental observations, the centrifugal force has prominent effect on the dyed water flow. Also, the effect of bend angle is investigated on the surface-driven capillary flow of water. The polystyrene microparticles have been separated in the microfluidic lab-on-a-chip systems using the investigated flow features. A 100\% separation efficiency is achieved in these lab-on-a-chip systems. These microfluidic lab-on-a-chip systems can be used to separate blood cells from human whole blood for further clinical tests. These experimental studies are important in bioengineering applications. The effect of bend angle as channel geometry to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems. Also, the effect of surface wettability as surface property to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems. © 2017 World Scientific Publishing Company.

Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in Microfluidic Lab-On-A-Chip systems for bioengineering applications

Microfluidics and Nanofluidics

Separation of micro-particles utilizing spatial difference of optically induced dielectrophoretic forces

Sensors and Actuators B: Chemical

Passive microfluidic devices for plasma extraction from whole human blood

Analytical Chemistry

Integration of Low-Power Microfluidic Pumps with Biosensors within a Laboratory-on-a-Chip Device

Bonding of thermoplastic polymer microfluidics

Journal of Micromechanics and Microengineering

Diamond and diamond-like carbon MEMS

Experimental studies of surface-driven capillary flow in PMMA microfluidic devices prepared by direct bonding technique and passive separation of microparticles in microfluidic laboratory-on-a-chip systems