Header menu link for other important links
Enantioselective intramolecular formal [2 + 4] annulation of acrylates and α,β-unsaturated imines catalyzed by amino acid derived phosphines
Z. Jin, R. Yang, Y. Du, B. Tiwari, , Y.R. Chi
Published in
PMID: 22676162
Volume: 14
Issue: 12
Pages: 3226 - 3229
The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described. The catalytic reactions afford N-heterocycles with exceptionally high diastereo- and enantioselectivities. The [2 + 4] products are amenable for further transformations to useful molecules such as chiral piperidines and multicyclic structures. © 2012 American Chemical Society.
About the journal
Published in
Open Access
Impact factor