Header menu link for other important links
Directing-group-assisted manganese-catalyzed cyclopropanation of indoles
Dutta P.K., Chauhan J., Ravva M.K.,
Published in American Chemical Society
PMID: 30860389
Volume: 21
Issue: 7
Pages: 2025 - 2028
The first manganese-catalyzed cyclopropanation of indoles is reported in moderate to excellent yield with methyl-2-diazo-2-arylacetates. This new strategy involved acetyl (COCH 3 ) as the directing group and exhibited exceptional functional group tolerance. In the absence of stereodirecting groups the desired products were obtained as a mixture of diastereomers (7:3 → 8:2). Control experiments and DFT studies elucidated the probable pathway for the formation of cyclopropane-fused indole product. Deacetylation of the final products afforded both C3-substituted NH-indoles. © 2019 American Chemical Society.
About the journal
Published in American Chemical Society
Open Access
Impact factor