A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity. © The Royal Society of Chemistry 2015.

Animesh Samanta

Chemistry

(SoNS) School of Natural Sciences

L. Zhang

J.C. Er

X. Li

J.J. Heng

Y.-T. Chang

C.-L.K. Lee

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Shiv Nadar University

Chemical Communications

Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach