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Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach
L. Zhang, J.C. Er, X. Li, J.J. Heng, , Y.-T. Chang, C.-L.K. Lee
Published in Royal Society of Chemistry
PMID: 25824610
Volume: 51
Issue: 34
Pages: 7386 - 7389
A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity. © The Royal Society of Chemistry 2015.
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Published in Royal Society of Chemistry
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