This work reports a detailed and systematic theoretical study of the anisotropic thermoelectric properties of bulk Germanium Sulfide (GeS) in its orthorhombic Pnma phase. Density functional theory (DFT), employing the generalized gradient approximation (GGA), has been used to examine the structural and electronic band structure properties of bulk GeS. Electronic transport properties have been studied by solving semiclassical Boltzmann transport equations. A machine-learning approach has been used to estimate the temperature-dependent lattice part of thermal conductivity. The study reveals that GeS has a direct band gap of 1.20 eV. Lattice thermal conductivity is lowest along crystallographic a-direction, with a minimum of ∼0.98 Wm −1 K −1 at 700 K. We have obtained the maximum figure of merit (ZT) ∼ 0.73 at 700 K and the efficiency ∼7.86% in a working temperature range of 300 K-700 K for pristine GeS along crystallographic a-direction. © 2022 IOP Publishing Ltd.