Two commercial diatomaceous earths were used as supports for the preparation of Mn/Co binary metal catalysts at different metal loads (5 to 10 wt \% Mn and 5 to 15 wt \% Co) by incipient wetness deposition. The activity of the prepared catalysts towards the complete oxidation of benzene to CO2 and water was investigated between 100 and 400◦ C. Raw supports and synthesized catalysts were characterized by XRD, N2 physisorption, SEM-EDS, H2 -TPR, and TPD. The purification treatment of food-grade diatomite significantly affected the crystallinity of this support while reducing its specific surface area (SSA). A loss of SSA, associated with the increase in the metal load, was observed on samples prepared on natural diatomite, while the opposite trend occurred with food-grade diatomite-supported catalysts. Metal nanoparticles of around 50 nm diameter were observed on the catalysts’ surface by SEM analysis. EDS analysis confirmed the uniform deposition of the active phases on the support’s surface. A larger H2 consumption was found by TPR analysis of natural diatomite-based samples in comparison to those prepared at the same metal load on food-grade diatomite. During the catalytic oxidation experiment, over 90\% conversion of benzene were achieved at a reaction temperature of 225◦ C by all of the prepared samples. In addition, the formation of coke during the oxidation tests was demonstrated by TGA analysis and the soluble fraction of the produced coke was characterized by GC-MS. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.